Ono Pharma Foundation Symposium

20 posters will be presented in this interactive session. Post-docs, students and young scientists working in the fields of Chemical Biology Research and Oligonucleotide Medicine Research are invited. Please join us and use this opportunity to learn the advanced research and partake in discussions and networking with other attendees.

1. Mierav Segal, BIDMC, Hydrophobically-modified let-7b miRNA conjugate enhances biodistribution to NSCLC and downregulates HMGA2 in vivo
2. Wenjian Wang, Boston College, Protein surface recognition via chemically enhanced phage display
3. Chao Liu, Boston College, Facile Sulfation of Carbohydrates and Peptides via Electron-Deficient Aryl Sulfate Diesters
4. Daniel Bak, Boston College, Chemoproteomic Studies of the Iron-Sulfur Proteome
5. Allyson Freedy, Harvard University, CRISPR-suppressor scanning reveals a non-enzymatic role of LSD1 in AML
6. Kevin Ngan, Harvard University, Activity-based CRISPR-scanning of DNMT1 and UHRF1
7. Yuka Amako, Harvard University, Enantiospecific binding site hotspot mapping of the immunomodulatory drugs
8. David Miyamoto, Harvard University, Discovery of functional metabolite–protein binding site hotspots
9. Robert M. Wilson, MIT, Chemical Screening Against the Pluripotency Factor LIN28
10. Andrew Chen, MIT, Discovery and Characterization of a Small Molecule that Modulates c-Myc Mediated Transcription via Max Homodimer Stabilization
11. Jonnell Small, Broad Institute, Investigating the Mechanisms of Beta-Cell Glucolipotoxicity Protective Small Molecules
12. Jameson Dahlin, Broad Institute, Unbiased cellular morphology profiling for the evaluation of cellular toxicities and assay interferences
13. Luke Koblan, Broad Institute, In vivo Correction of Pathogenic SNPs with Optimized Base Editors
14. Tony Huang, Broad Institute, Circularly permuted and PAM-modified base editors with broadened targeting scope
15. Christopher Gerry, Broad Institute, Incorporating Topographically Complex Small Molecules into DNA-Encoded Libraries
16. Matthias Westphal, Broad Institute, Harnessing unusual reactivity for DNA-encoded library synthesis
17. Min Wook Shin, University of Massachusetts, Distribution and Effect of Intratracheally Administered Antisense Oligonucleotides on Different Lung Cell Populations
18. Juta Kobayshi, Ono Pharmaceutical, NMR-based analysis of protein-ligand interactions towards drug discovery
19. Takayuki Inukai, Ono Pharmaceutical, Targeting Dynamic ATP-Binding Site Features Allows Discrimination between Highly Homologous Protein Kinases
20. Kenji Sasaki, Ono Pharmaceutical, Ligand and Target Discovery by Fragment-Based Screening in Human Cells